BONE CONDITION IN RATS UNDER THE BACKGROUND OF INTOXICATION WITH ALUMINUM CHLORIDE AND LIPID PEROXIDES
DOI: https://doi.org/10.17721/1728.2748.2025.103.88-92
Keywords:
peroxidized oil, aluminum chloride, bone tissue, rats.Abstract
Background. Long -term use of xenobiotics, as well as transparent foods leads to a generalized outbreak of lipid peroxidation in the body, disruption of the system of antioxidant protection, activation of inflammatory processes, increased bone resorption, adversely affects the condition of the liver as the main organ of detoxification. The purpose of the work was to study the condition of the bones of rats with the compatible administration of aluminum chloride and peroxidized oil.
Methods. The following methods were used: determination of atrophy of the alveolar process of jaws, determination of bone density, biochemical methods for determining the state of bone tissue and the condition of the mucous membrane of the oral cavity (SOPR). The research was conducted on 40 3-month males of the Rats of Vistar. Rat research groups: 1) intact - rats on the standard vivarium diet; 2) adding to the feed of peroxidized oil; 3) introduction of aluminum chloride solution; 4) compatible use of transoxized oil and aluminum chloride.
Results. A decrease in the density of the femur and lumbar vertebrae, increased atrophy of the alveolar process, a significant impairment of bone metabolism in the jaws of animals, which were subjected to peroxidized oil or aluminum salt, namely, and an increase in resorption on the background of bone braking, has been revealed. The most pronounced pathological changes are registered in the bone tissue of rats, which were obtained simultaneously with transparent oil and ALCL3.
Conclusions. The obtained results indicate the ability of harmful factors (transparent oil and ALCL3), which have acted for a long time, to increase the resorption of bone tissue of the jaws, the femur and lumbar vertebrae of experimental animals. The set of these factors has caused the most active processes of bone destruction, which is a condition for the development of osteopathy.
References
Broomandi, P., Guney, M., Kim, J. R., & Karaca, F. (2020). Soil contamination in areas impacted by military activities: A critical review. Sustainability, 12(21), Article 9002. https://doi.org/10.3390/su12219002
Govorukha, O. Yu., & Shnaiderman, O. Yu. (2016). The significance of the interaction of lipid peroxidation and antioxidant systems in the development of pathological processes. Theoretical and Experimental Medicine, 4, 10–14 [in Ukrainian].
Kanzyuba, A. I., & Shtroblya, V. V. (2022). Pathogenetic and pharmacological problems of bone homeostasis in osteoporosis. Medical Affairs, 3–4(1163), 5–14 [in Ukrainian]. https://doi.org/10.31640/2706-8803-2022-(3-4)-01
Labush, Yu. Z., & Markov, A. V. (2023). The relationship between diseases of the oral mucosa and pathology of the gastrointestinal tract. Current Problems of Modern Medicine, 23(2.82), 140–144 [in Ukrainian]. https://doi.org/10.31718/2077-1096.23.2.2.140
Makarenko, O. A., Khromakhina, L. M., Khodakov, I. V., Maikova, H. V., Mudryk, L. M., Kika, V. V., & Mohilevska, T. V. (2022). Methods of studying the state of intestines and bones in laboratory rats. Publisher S. L. Nazarchuk (Ed.) (pp. 41–79) [in Ukrainian].
Noh, J. Y., Yang, Y., & Jung, H. (2020). Molecular mechanisms and emerging therapeutics for osteoporosis. International Journal of Molecular Sciences, 21(20), Article 7623. https://doi.org/10.3390/ijms21207623
Rahimzadeh, M. R., Rahimzadeh, M. R., Kazemi, S., Amiri, R.-J., Pirzadeh, M., & Moghadamnia, A. A. (2022). Aluminum poisoning with emphasis on its mechanism and treatment of intoxication. Emergency Medicine International, 2022, Article 1480553. https://doi.org/10.1155/ 2022/1480553
Ruigrok, R. A., Weersma, R. K., & Vich Vila, A. (2023). The emerging role of the small intestinal microbiota in human health and disease. Gut Microbes, 15(1), 2201155. https://doi.org/10.1080/19490976.2023.2201155
Schifman, R. B., & Luevano, D. R. (2018). Aluminum toxicity: Evaluation of 16-year trend among 14 919 patients and 45 480 results. Archives of Pathology & Laboratory Medicine, 142(6), 742–746. https://doi.org/ 10.5858/arpa.2017-0049-OA
Shnaider, S. A., & Levitsky, A. P. (2017). Experimental dentistry. Part I. Experimental models of dental diseases. Odesa City Printing House [in Ukrainian].
Stewart, S., Darwood, A., Masouros, S., Higgins, C., & Ramasamy, A. (2019). Mechanotransduction in osteogenesis. Bone & Joint Research, 9(1), 1–14. https://doi.org/10.1302/2046-3758.91.BJR-2019-0043.R2
