STUDY OF ANTI-INFLAMMATORY, ANTIOXIDANT AND ANTICYTOLYTIC PROPERTIES OF GRAPE SEED OIL
DOI 10.17721/1728.2748.2022.88.15-24
Keywords:
grape seed oil, acidification, alteration, antioxidant activity, lipid peroxidation, basic glutathione, antioxidant properties, cytodegradative processesAbstract
A complex of local disturbances, which occurs as a result of tissue damage and microbial invasion, appears in the form of disorder of microcirculation, In metabolichnyh disorder under the influence of inflammation mediators and progressive hypoxia, lead to the development of pathological states. As a result develop hyperhydration of tissues, bloating, in extreme cases, death of cells, necrosis. The role of secondary damage factor in the inflammation is played by the activation of radical processes. It was found that the mechanisms of activation of LPO included already in the early stages of hypoxia tissues, which necessarily develop in the ignition fire. Therefore, the search for new anti-inflammatoryand wound healing photopreparations is relevant for medicine. Investigation of the influence of grape seed oil on the development of the flammation process with a pronounced exudative and alterative component, study of the antioxidantand anticytolytic activity of the investigated oil against a background of model pathology. Antipyretic properties of grape seed oil were studied using models of hot flame of the mice's ends and of severe aseptic environmental foot odour in beetles caused by the action of different phlogogens (caragenin and zymosan). The effect of grape seed oil on the exudative component of the inflammatory reaction was investigated by determining the degree of penetration of the capillary wall. The effect of the investigated oil on the course of the flammatory reaction with a pronounced alterative component was studied on the model of aseptic inflammation of the skin and of the hypodermic cell. Grape seed oil and the confounding preparation (olive oil, silibor) normalized the antioxidant status of cells as indicated by the increased level of total glutathione in all groups of test animals up to the level of the intact control.The application of grape seed oil normalised the activity of marker enzymes and urea levels in the blood serum of experimental animals. Grape seed oil exhibits diverse anti-flammatory properties which are conditioned by antagonism with flame mediators (mainly leukotrienes). It was found that for the widespread antiinflammatory effect on the model of thermal burning of the ends of the mice and zymozanovogo ignition. foot in the snapper grape seed oil tends to outperform the drug in comparison with olivine olio. Introduction of grape seed oil significantly reduces the permeability of the vessel wall on the model of increased vessel permeability, which was created by the introduction of three phlogogens. On the model of aseptic inflammation of the skin and hypodermic cells in acetic acid-induced gnats, it was also found that grape seed oil produces a pronounced therapeutic effect, which is probably manifested by an increase in reparative processes. At the model of tetrachloromethane hepatitis grape seed oil showed antioxidant activity, which was more visible in relation to the antioxidant action of the preparation of olive oil.Against the background of extruded stencil wounds, the use of the investigated oil reduced the severity of cytodestructive processes by reducing the activity of marker enzymes of cytolysis and urea content, which were at the level of the reference drug, sea buckthorn oil.
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