CONCENTRATION OF C-REACTIVE PROTEIN AND CONTENT OF MIDDLE MOLECULES IN BLOOD PLASMA OF PATIENTS WITH OSTEOARTHRITIS AFTER SARS-CoV 2-INFECTION
DOI 10.17721/1728.2748.2022.88.47-50
Keywords:
SARS-CoV-2, osteoarthritis, inflammationAbstract
The new coronavirus disease of 2019 (COVID-19) poses an important and urgent threat to the health of people around the world. The topical issue is the prediction of chronic diseases in people with coronavirus infection. Such chronic diseases include osteoarthritis, which affects a large population. Inflammation is an integral part of the development of osteoarthritis, so the study of its markers can assess the severity of the disease. The aim of the study was to determine the concentration of C-reactive protein and molecules of average molecular weight in the blood plasma of patients with osteoarthritis after SARS-CoV2 infection. The study involved 28 people aged 39 to 70 years. Volunteers were divided into the following groups: the first group – relatively healthy people, the second group – patients with osteoarthritis of the knee II-III degree, the third group – patients with osteoarthritis of the knee II-III degree who have recovered from COVID-19. Indicators of inflammation were determined in human blood plasma. The concentration of C-reactive protein was determined by turbidimetric method. The content of molecules of average molecular weight was determined by screening. Processing of research results was carried out by generally accepted methods of variation statistics. It was found that in the blood plasma of patients with osteoarthritis of the knee joints who recovered from COVID-19, the concentration of C-reactive protein and the content of molecules of average molecular weight increases more compared to the group of patients with osteoarthritis of the knee joints. The identified changes indicate the development of more intense inflammation in the blood of patients with osteoarthritis after SARS-CoV2 infection. To understand the mechanisms of formation of more severe osteoarthritis and the possible development of complications in patients with post-COVID-19 syndrome, it is necessary to conduct further studies of this comorbid pathology.
References
Lio D., Scola L., Giarratana R. M., Candore G., Colonna-Romano G., Caruso C., Balistreri C. R. SARS CoV2 infection _The longevity study perspectives. Ageing Res Rev. 2021, May; 67:101299. doi: 10.1016/j.arr.2021.101299.
Tirelli U., Taibi R., Chirumbolo S. Post COVID syndrome: a new challenge for medicine. Eur Rev Med Pharmacol Sci. 2021, Jun; 25(12):4422-4425. doi: 10.26355/eurrev_202106_26154.
Wood M. J., Miller R. E., Malfait A. M. The genesis of pain in osteoarthritis: inflammation as a mediator of osteoarthritis pain. Clin Geriatr Med. 2022, May 38(2); 221-238. doi: 10.1016/j.cger.2021.11.013
Hadi Jassim M., Shukur H. Y., Rabeea H. W. Radiography of osteoarthritis as an abnormal anatomical change in geriatrics. Wiad Lek. 2021; 74(12):3168-3171.
Lai Q., Spoletini G., Bianco G., Graceffa D., Agnes S., Rossi M., Lerut J. SARS-CoV2 and immunosuppression: A double-edged sword. Transpl Infect Dis. 2020, Dec; 22(6):e13404. doi: 10.1111/tid.13404. Epub 2020 Jul 17.
Gasmi A., Tippairote T., Mujawdiya P. K., Gasmi Benahmed A., Menzel A., Dadar M., Bjørklund G. Neurological Involvements of SARS-CoV2 Infection. Mol Neurobiol. 2021, Mar; 58(3):944-949. doi: 10.1007/s12035-020-02070-6.
Li Z., Huang Z., Bai L. Cell Interplay in Osteoarthritis. Front Cell Dev Biol. 2021, Aug;3(9):720477. doi:10.3389/fcell.2021.720477.
Sanchez-Lopez E., Coras R., Torres A., Lane N. E., Guma M. Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol. 2022, Feb; 14. doi: 10.1038/s41584-022-00749-9.
V.V. Dolgov [i dr.]. Turbidimetriya v laboratornoj praktike, M.: Reafarm, 2007; c176.
Gabrielyan N. I. Skriningovyj metod opredeleniya srednih molekul v biologicheskih zhidkostyah: Metodicheskie rekomendacii. : Mir; 1985, c. 11.
Nicola R. Sproston and Jason J. Ashworth* Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018; 9: 754. doi: 10.3389/fimmu.2018.00754
Wu Y., Potempa L. A., El Kebir D., Filep J. G. C-reactive protein and inflammation: conformational changes affect function. Biol Chem. 2015; 396: 1181–97. doi:10.1515/hsz-2015-0149
M. Hanada, M. Takahashi, H. Furuhashi, H. Koyama, Y. Matsuyama. Elevated erythrocyte sedimentation rate and high-sensitivity C-reactive protein in osteoarthritis of the knee: relationship with clinical findings and radiographic severity/ Ann Clin Biochem, 2016; 53(5): 548-553, doi: 10.1177/0004563215610142
M. Sharif 1., L. Shepstone, C. J. Elson, P. A. Dieppe, J. R. Kirwan Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis. 2000, Jan; 59(1):71-4. doi: 10.1136/ard.59.1.71.
Kerkhof H. J., Bierma-Zeinstra S. M., Castano-Betancourt M. C., de Maat M. P., Hofman A., Pols H. A., et al. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis, 2010; 69(11):1976e82, https://doi.org/10.1136/ard.2009.125260.
Jin X., Beguerie J. R., Zhang W., Blizzard L., Otahal P., Jones G., et al. Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis, 2015; 74(4):703e10, https://doi.org/10.1136/annrheumdis-2013-204494.
Sidelnikova V. I., Chernitskii A. E., Retsky M. I. Endogenous intoxication and inflammation: A sequence of reactions and markers' informativeness. Agric. Biol. 2015; 50:152–161.
William H. Robinson, Christin M. Lepus, Qian Wang, Harini Raghu, Rong Mao, Tamsin M. Lindstrom, Jeremy Sokolove Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol., 2016, Oct; 12(10):580-92. doi: 10.1038/nrrheum.2016.136. Epub 2016 Aug 19.
